Microthane® & MESMO® Studien

Microthane®* clinical articles

2026

Buriciaga Soto and Rendon Meja. Five-year Patient-reported Outcomes Following Primary Breast Augmentation With Polyurethane-coated Implants: Development and Preliminary Validation of a Device-specific Instrument. Aesthet Surg J. 2026 Jun 26:sjag129. doi: 10.1093/asj/sjag129
Hernandez et al. Immediate breast reconstruction with Polyurethane-Coated implants following mastectomy: Early experience and short-term outcomes. 2026, 39(2). doi.org/10.1016/j.senol.2026.100750
Kurt et al. Prepectoral Breast Reconstruction with Polyurethane-Coated Implants: A 117-Patient Single-Center Study with Objective Cosmetic Evaluation. Aesthetic Plast Surg
. 2026 May 18. doi: 10.1007/s00266-026-05901-4
Mele et al. Augmentation Mastopexy with Polyurethane-Coated Implants in the Prepectoral Plane: A 24-Month Follow-Up Study. Aesthetic Surgery Journal Open Forum Aesthetic Surgery Journal Open Forum, 2026;, ojag118, https://doi.org/10.1093/asjof/ojag118
Rahman et al., Comparative Analysis of Prepectoral and Subpectoral Standalone Placement of Microthane Breast Implants in Post-Mastectomy Breast Reconstruction: A Retrospective Study. JPRAS Open (2026), doi.org/10.1016/j.jpra.2026.01.028
Salgarello et al., The impact of postmastectomy radiation therapy on immediate prepectoral reconstruction with polyurethane-coated implants. Aesthetic Plast Surg. 2026 Jan;50(1):171-180. doi: 10.1007/s00266-025-05119-w
Wimmer K, Kiblawi R, Fitzal F, et al. The impact of polyurethane coated implants on the risk of capsular contracture after immediate prepectoral breast reconstruction in the setting of postmastectomy radiotherapy: The OPBC-09 PRExRT study. In: European Journal of Cancer. Vol 237. 2026:1-157. doi.org/10.1016/j.ejca.2026.116301

2025

Bruno E, Cilluffo M, Columpsi A, et al. Standalone Microthane® breast implants in the prepectoral position: Positive outcomes from combining technical and surgical advantages supported by patient-reported outcomes. JPRAS Open. 2025;46:654-665. doi:10.1016/j.jpra.2025.10.021
Caimi E, Vaccari S, Furlan S, et al. Post-Mastectomy Direct-to-Implant Pre-Pectoral Breast Reconstruction With Polyurethane-Coated Implants: A Systematic Review of Efficacy and Safety. Aesthetic Surg J Open Forum. 2025;7:ojaf162. doi:10.1093/asjof/ojaf162
Elsaftwi et al., Breast Reconstruction in a Female Patient With Poland Syndrome. Plast Reconstr Surg Glob Open . 2025 Aug 27;13(8):e7076. doi.org/10.1097/gox.0000000000007076
Lisa et al., Outcomes, indications and predictive factors for complications in postmastectomy prepectoral reconstructions with polyurethane foam-coated implants. The Breast, Volume 83, 104520 (2025). doi.org/10.1016/j.breast.2025.104520
Pagliara D, Pili N, Serra PL, et al. Improving Outcomes in Immediate Prepectoral Reconstruction of Large and Ptotic Breast: The Reliability of Fifth Anterior Intercostal Artery Perforator Flap. Clin Breast Cancer. 2025;25(5):e578-e587. doi:10.1016/j.clbc.2025.02.012
Pierazzi et al., Nipple-Sparing Skin-Reducing Mastectomy and Immediate Prepectoral Breast Reconstruction: A New Surgical Approach. Aesthet Surg J Open Forum. 2025 Nov 4:7:ojaf133. doi: 10.1093/asjof/ojaf133.
Quattrini-Li et al., The SIMPLE Technique for Unilateral Breast Reconstruction with Moderate Ptosis: Aiming for Durable Symmetry. Aesthet Surg J Open Forum. 2025 Dec 30:8:ojaf173. doi: 10.1093/asjof/ojaf173
Salgarello et al. Can the Use of Closed Incision Negative Pressure Wound Therapy in Immediate Prepectoral Breast Reconstruction with Polyurethane-Coated Implants Reduce the Rate of Early Complications?: A Comparative Study. Aesthet Surg J. 2025 Oct 23:sjaf211. doi: 10.1093/asj/sjaf211
Salgarello et al., Prepectoral Breast Reconstruction: Early and Long-term Complications and Outcomes of Total Coverage ADM and Implants vs Polyurethane-Coated Implants Without Use of Acellular Dermal Matrix. Aesthet Surg J. 2025 Aug 8 https://doi.org/10.1093/asj/sjaf158
Salgarello, M., Fabbri, M., Visconti, G. et al. Immediate Breast Reconstruction with Prepectoral Polyurethane-Covered Implant After Conservative Mastectomy in Large and Ptotic Breasts. Aesth Plast Surg (2025). https://doi.org/10.1007/s00266-025-05070-w
Tulin et al. Video-Assisted Mastectomy with Immediate Breast Reconstruction: First Clinical Experience and Outcomes in an Eastern European Medical Center. Cancers (Basel). 2025 Jul 7;17(13):2267. doi: 10.3390/cancers17132267
Visconti G, Mendanha M. Versatility of Diagon\Gel 4Two Implants in Aesthetic and Reconstructive Breast Surgery. Aesthetic Plast Surg. 2025;49(9):2467-2475. doi: 10.1007/s00266-024-04631-9

2024

Barone Adesi L, Taraschi F, Macrì G, et al. Fat Grafting and Prepectoral Prosthetic Reconstruction with Polyurethane-Covered Implants: Protective Role against Adjuvant Radiotherapy. J Clin Med. 2024;13(17):4982. doi:10.3390/jcm13174982
Catanuto et al., One-Stage Implant-Based Breast Reconstruction With Polyurethane-Coated Device: Standardized Assessment of Outcomes. Aesthet Surg J. 2024;44(5):491-498. doi:10.1093/asj/sjad301
Corriea-Pinto et al., Impact of polyurethane versus acellular dermal matrix coating on prepectoral reconstruction outcomes: Interface does matter. J Plast Reconstr Aesthet Surg. 2024;91:15-23. doi:10.1016/j.bjps.2024.01.025
Felici et al. long-term results in postmastectomy breast reconstruction with polyurethane-coated implants. Plast Reconstr Regen Surg. 2024;3(3):71-75. doi: 10.57604/PRRS-659
García-Novoa A, Acea-Nebril B, López-Domínguez C, et al. Local Flaps to Cover Skin Necrosis after Skin-sparing Mastectomy and Prepectoral Reconstruction from PreQ-20 Trial. Plast Reconstr Surg Glob Open. 2024;12(1):e5510. Published 2024 Jan 8. doi:10.1097/GOX.0000000000005510
Hamdi M, Kapila AK, Peters E, et al. Polyurethane Implants in Revisional Breast Augmentation: A Prospective 5-Year Study. Aesthet Surg J. 2024;44(6):NP379-NP390. doi:10.1093/asj/sjae047
Lembo F, Cecchino LR, Parisi D, Portincasa A. Immediate Breast Reconstruction in Skin-Reducing Mastectomy with Prepectoral Polyuretane (Pu) Implant Covered with an Autologous Dermo-Adipose Flap. Aesthetic Plast Surg. 2024;48(15):2829-2838. doi:10.1007/s00266-022-03240-8
Pagliara D, Rubino C, Grieco F, et al. Technical Refinements and Outcomes Assessment in Prepectoral Pocket Conversion After Postmastectomy Radiotherapy. Aesthet Surg J. 2024;44(6):624-632. doi:10.1093/asj/sjae012

2023

Acea-Nebril et al., Immediate breast reconstruction by prepectoral polyurethane implant: Preliminary results of the prospective study PreQ-20. ir Esp (Engl Ed). 2023 Mar;101(3):187-197. doi: 10.1016/j.cireng.2022.09.021
Acea-Nebril et al., Safety and Quality of Life in Women with Immediate Reconstruction with Polyurethane Implants after Neoadjuvant Chemotherapy: Outcomes from The Preq-20 Trial. Cancers (Basel). 2023 Feb 9;15(4):1113. doi: 10.3390/cancers15041113
Cagli B, Carotti S, Segreto F, et al. Histologic and Immunohistochemical Evaluation of Human Breast Capsules Formed around Five Different Expander Surfaces. Plast Reconstr Surg. 2023;152(3):388e-397e. doi:10.1097/PRS.0000000000010317
Corriea-Pinto et al., Comparing polyurethane and acellular dermal matrix implant cover in prepectoral breast reconstruction: short-term complications. Plast Reconstr Surg Glob Open. 2023 Feb 2;11(2):e4798. doi: 10.1097/GOX.0000000000004798.
Loreti et al., Surgical Delay of Nipple Areola Complex: A Powerful technique to Extend the Indication of Nipple-Sparing Mastectomy. Clin Breast Cancer. 2023 Apr;23(3):255-264. doi: 10.1016/j.clbc.2023.01.003.
Pagliara D, Montella RA, Garganese G, et al. Improving Decision-making in Prepectoral Direct-to-implant Reconstruction After Nipple Sparing Mastectomy: The Key Role of Flap Thickness Ratio. Clin Breast Cancer. 2023;23(2):e37-e44. doi:10.1016/j.clbc.2022.11.007

2022

de Vita et al., Extended Clinical Experience With Nipple-Sparing Mastectomy and Prepectoral Polyurethane Implant Positioning (BRAND4P method). Clin Breast Cancer. 2022;22(5):e623-e628. doi:10.1016/j.clbc.2022.03.005
Scardina et al., Prepectoral vs. Submuscular immediate breast reconstruction in patients undergoing mastectomy after neoadjuvant chemotherapy: our early experience J Pers Med. 2022 Feb 22;11(2):153. doi: 10.3390/jpm11020153.

2021

Coyette et al., Prepectoral immediate breast reconstruction with polyurethane foam-coated implants: feasibility and early results in risk-reducing and therapeutic mastectomies. J Plast Reconstr Aesthet Surg . 2021 Nov;74(11):2876-2884. doi: 10.1016/j.bjps.2021.03.077.
Franceschini et al., Immediate prosthetic breast reconstruction after nipple-sparing mastectomy: traditional subpectoral technique versus direct-to-implant prepectoral reconstruction without acellular dermal matrix. J Pers Med . 2021 Feb 22;11(2):153. doi: 10.3390/jpm11020153
Salgarello et al., Direct to Implant Breast Reconstruction With Prepectoral Micropolyurethane Foam-Coated Implant: Analysis of Patient Satisfaction. Clin Breast Cancer. 2021;21(4):e454-e461. doi:10.1016/j.clbc.2021.01.015
Scardina et al. Nipple sparing mastectomy with prepectoral immediate prosthetic reconstruction without acellular dermal matrices: a single center experience. Minerva Surg. 2021 Dec;76(6):498-505. doi: 10.23736/S2724-5691.21.08998-X

2020

Loreti et al. Immediate Breast Reconstruction after mastectomy with polyurethane implants versus textured implants: A retrospective study with focus on capsular contracture. Breast. 2020;54:127-132. doi:10.1016/j.breast.2020.09.009
Neamonitou et al. Outcome of complete acellular dermal matrix wrap with polyurethane implant in immediate prepectoral breast reconstruction. Arch Plast Surg . 2020 Nov;47(6):567-573. doi: 10.5999/aps.2020.01207
Salgarello and Visconti; Short-Scar Augmentation Mastopexy in Massive-Weight Loss Patients: Four-Step Surgical Principles for Reliable and Reproducible Results. Aesthetic Plast Surg . 2020 Apr;44(2):272-282. doi: 10.1007/s00266-019-01540-0

2018

Lo Torto F, Relucenti M, Familiari G, et al. The Effect of Postmastectomy Radiation Therapy on Breast Implants: Material Analysis on Silicone and Polyurethane Prosthesis. Ann Plast Surg. 2018;81(2):228-234. doi:10.1097/SAP.0000000000001461

2017

Pompei et al., Polyurethane Implants in 2-Stage Breast Reconstruction: 9-Year Clinical Experience. Aesthet Surg J. 2017;37(2):171-176. doi:10.1093/asj/sjw183
Stan C, Biggs T. The Diagon/Gel Implant: A Preliminary Report of 894 Cases. Plast Reconstr Surg Glob Open. 2017;5(7):e1393. Published 2017 Jul 5. doi:10.1097/GOX.0000000000001393

2016

Pompei et al., The Modern Polyurethane-Coated Implant in Breast Augmentation: Long-Term Clinical Experience [published correction appears in Aesthet Surg J. 2017 Jul 1;37(7):854. doi: 10.1093/asj/sjw237.]. Aesthet Surg J. 2016;36(10):1124-1129. doi:10.1093/asj/sjw171

2015

Brunnert KE. The micropolyurethane foam-coated Diagon/Gel(®)4Two implant in aesthetic and reconstructive breast surgery - 3-year results of an ongoing study. GMS Interdiscip Plast Reconstr Surg DGPW. 2015;4:Doc20. Published 2015 Dec 21. doi:10.3205/iprs000079

Microthane® and MESMO® clinical articles

Microthane®* clinical articles

MESMO® clinical articles